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Article

ENaC channels in oocytes from Xenopus laevis and their regulation by xShroom1 protein.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2011

Assef Yanina A, Ozu Marcelo, Marino Gabriela I, Galizia Luciano, Kotsias Basilio A

Abstract excerpt

Shroom is a family of related proteins linked to the actin cytoskeleton. xShroom1 is constitutively expressed in X. oocytes and is required for the expression of amiloride sensitive sodium channels (ENaC). Oocytes were injected with α, β, and γ mENaC and xShroom1 sense or antisense oligonucleotides. We used voltage clamp techniques to study the amiloride-sensitive Na(+) currents (INa((amil))). We observed a...

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PMID: 21865733
DOI: 10.1159/000331738

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