Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Open probability of the epithelial sodium channel is regulated by intracellular sodium.

The Journal of physiology - 15 Jul 2006

Anantharam Arun, Tian Yuan, Palmer Lawrence G

Abstract excerpt

The regulation of epithelial Na(+) channel (ENaC) activity by Na(+) was studied in Xenopus oocytes using two-electrode voltage clamp and patch-clamp recording techniques. Here we show that amiloride-sensitive Na(+) current (I(Na)) is downregulated when ENaC-expressing cells are exposed to high extracellular [Na(+)]. The reduction in macroscopic Na(+) current is accompanied by an increase in the concentration of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brefeldin A
Share to Electrophysiology
Share to Epithelial Sodium Channels

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Feedback, Physiological

Share to Mesylates

Share to Protein Synthesis Inhibitors

Share to Sodium

Share to Sodium Channels

Source

Open in PubMed Open full text

Identifiers

PMID: 16690707
DOI: 10.1113/jphysiol.2006.109173
PMCID: PMC1817776

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Open probability of the epithelial sodium channel is regulated by intracellular sodium.PMID 16690707Read ↗

Novel determinants of epithelial sodium channel gating within extracellular thumb domains.Semantic proximity Read ↗

Opposite effects of Ni2+ on Xenopus and rat ENaCs expressed in Xenopus oocytes.Semantic proximity Read ↗

The epithelial sodium channel (ENaC): new insights into ENaC gating.Semantic proximity Read ↗

A mutation of the epithelial sodium channel associated with atypical cystic fibrosis increases channel open probability and reduces Na+ self inhibition.Semantic proximity Read ↗

Syntaxin 1A regulates ENaC channel activity.Semantic proximity Read ↗

Mutations in the extracellular loop of alpha-rENaC alter sensitivity to amiloride and reactive species.Semantic proximity Read ↗

Asymmetric organization of the pore region of the epithelial sodium channel.Semantic proximity Read ↗

A mutation causing pseudohypoaldosteronism type 1 identifies a conserved glycine that is involved in the gating of the epithelial sodium channel.Semantic proximity Read ↗

A mutation in the epithelial sodium channel causing Liddle disease increases channel activity in the Xenopus laevis oocyte expression system.Semantic proximity Read ↗

Gain-of-function variant of the human epithelial sodium channel.Semantic proximity Read ↗

Side chain orientation of residues lining the selectivity filter of epithelial Na+ channels.Semantic proximity Read ↗

Regulation and amiloride-binding site of epithelial Na+ channels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.