Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Syntaxin 1A regulates ENaC channel activity.

The Journal of biological chemistry - 12 Mar 2004

Condliffe Steven B, Zhang Hui, Frizzell Raymond A

Abstract excerpt

Na(+) entry across the apical membranes of many absorptive epithelia is determined by the number (N) and open probability (P(o)) of epithelial sodium channels (ENaC). Previous results showed that the H3 domain of syntaxin-1A (S1A) binds to ENaC to reduce N, supporting a role for S1A in the regulation of ENaC trafficking. The aim of this study was to determine whether S1A-induced reductions in ENaC current also...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Surface
Share to Electrophysiology
Share to Epithelial Sodium Channels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to RNA, Complementary

Share to Sodium

Share to Sodium Channels

Share to Syntaxin 1

Share to Xenopus

Source

Identifiers

PMID: 14703519
DOI: 10.1074/jbc.M313592200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Syntaxin 1A regulates ENaC channel activity.PMID 14703519Read ↗

Syntaxin 1A inhibits CFTR chloride channels by means of domain-specific protein-protein interactions.Semantic proximity Read ↗

Open probability of the epithelial sodium channel is regulated by intracellular sodium.Semantic proximity Read ↗

The epithelial sodium channel (ENaC): new insights into ENaC gating.Semantic proximity Read ↗

A mutation causing pseudohypoaldosteronism type 1 identifies a conserved glycine that is involved in the gating of the epithelial sodium channel.Semantic proximity Read ↗

Genetic and electrophysiological studies of Drosophila syntaxin-1A demonstrate its role in nonneuronal secretion and neurotransmission.Semantic proximity Read ↗

H3 domain of syntaxin 1A inhibits KATP channels by its actions on the sulfonylurea receptor 1 nucleotide-binding folds-1 and -2.Semantic proximity Read ↗

The transmembrane domain of syntaxin 1A negatively regulates voltage-sensitive Ca(2+) channels.Semantic proximity Read ↗

Apical targeting of syntaxin 3 is essential for epithelial cell polarity.Semantic proximity Read ↗

SNARE expression and localization in renal epithelial cells suggest mechanism for variability of trafficking phenotypes.Semantic proximity Read ↗

Cys palmitoylation of the beta subunit modulates gating of the epithelial sodium channel.Semantic proximity Read ↗

Syntaxin 3B: A SNARE Protein Required for Vision.Semantic proximity Read ↗

Role of H(abc) domain in membrane trafficking and targeting of syntaxin 1A.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.