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Article

Study of human RIG-I polymorphisms identifies two variants with an opposite impact on the antiviral immune response.

PloS one - 27 Oct 2009

Pothlichet Julien, Burtey Anne, Kubarenko Andriy V, Caignard Gregory, Solhonne Brigitte, Tangy Frédéric, Ben-Ali Meriem, Quintana-Murci Lluis, Heinzmann Andrea, Chiche Jean-Daniel, Vidalain Pierre-Olivier, Weber Alexander N R, Chignard Michel, Si-Tahar Mustapha

Abstract excerpt

BACKGROUND: RIG-I is a pivotal receptor that detects numerous RNA and DNA viruses. Thus, its defectiveness may strongly impair the host antiviral immunity. Remarkably, very little information is available on RIG-I single-nucleotide polymorphisms (SNPs) presenting a functional impact on the host response. METHODOLOGY/PRINCIPAL FINDINGS: Here, we studied all non-synonymous SNPs of RIG-I using biochemical and...

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Identifiers

PMID: 19859543
DOI: 10.1371/journal.pone.0007582
PMCID: PMC2762520

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MAVS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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