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Ancient Origins of Vertebrate-Specific Innate Antiviral Immunity

8 Oct 2013

Abstract excerpt

Animals deploy various molecular sensors to detect pathogen infections. RIG-like receptor (RLR) proteins identify viral RNAs and initiate innate immune responses. The three human RLRs recognize different types of RNA molecules and protect against different viral pathogens. The RLR protein family is widely thought to have originated shortly before the emergence of vertebrates and rapidly diversified through a...

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PMID: 24109602
DOI: 10.1093/molbev/mst184

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