Article
Polymorphic trial in oxidative damage of arsenic exposed Vietnamese.
Toxicology and applied pharmacology - 15 Oct 2011
Fujihara Junko, Soejima Mikiko, Yasuda Toshihiro, Koda Yoshiro, Kunito Takashi, Iwata Hisato, Tanabe Shinsuke, Takeshita Haruo
Abstract excerpt
Arsenic causes DNA damage and changes the cellular capacity for DNA repair. Genes in the base excision repair (BER) pathway influence the generation and repair of oxidative lesions. Single nucleotide polymorphisms (SNPs) in human 8-oxoguanine DNA glycosylase (hOGG1) Ser326Cys; apurinic/apyrimidinic endonuclease (APE1) Asp148Glu; X-ray and repair and cross-complementing group 1 (XRCC1) Arg280His and Arg399Gln in...
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