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Article

Edgotype: a fundamental link between genotype and phenotype.

Current opinion in genetics & development - 1 Dec 2013

Sahni Nidhi, Yi Song, Zhong Quan, Jailkhani Noor, Charloteaux Benoit, Cusick Michael E, Vidal Marc

Abstract excerpt

Classical 'one-gene/one-disease' models cannot fully reconcile with the increasingly appreciated prevalence of complicated genotype-to-phenotype associations in human disease. Genes and gene products function not in isolation but as components of intricate networks of macromolecules (DNA, RNA, or proteins) and metabolites linked through biochemical or physical interactions, represented in 'interactome' network...

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Source

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Identifiers

PMID: 24287335
DOI: 10.1016/j.gde.2013.11.002
PMCID: PMC3902775

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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