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Article

Cellular features of senescence during the evolution of human and murine ductal pancreatic cancer.

Oncogene - 22 Mar 2012

Caldwell M E, DeNicola G M, Martins C P, Jacobetz M A, Maitra A, Hruban R H, Tuveson D A

Abstract excerpt

During tumor initiation, oncogene-induced senescence (OIS) is proposed to limit the progression of preneoplasms to invasive carcinoma unless circumvented by the acquisition of certain tumor suppressor mutations. Using a variety of biomarkers, OIS has been previously reported in a wide range of human and murine precursor lesions, including the pancreas, lung, colon and skin. Here, we have characterized a panel of...

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Identifiers

PMID: 21860420
DOI: 10.1038/onc.2011.350
PMCID: PMC3397306

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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