Article
Rising HIV-1 viral load set point at a population level coincides with a fading impact of host genetic factors on HIV-1 control.
AIDS (London, England) - 28 Nov 2011
van Manen Daniëlle, Gras Luuk, Boeser-Nunnink Brigitte D, van Sighem Ard I, Maurer Irma, Mangas Ruiz Marga M, Harskamp Agnes M, Steingrover Radjin, Prins Jan M, de Wolf Frank, van 't Wout Angélique B, Schuitemaker Hanneke
Abstract excerpt
OBJECTIVE: Heterozygosity for a 32 base pair deletion in the CCR5 gene (CCR5wt/Δ32) and the minor alleles of a single-nucleotide polymorphism in the HCP5 gene (rs2395029) and in the HLA-C gene region (-35HLA-C; rs9264942) has been associated with a lower viral load set point. Recent studies have shown that over calendar time, viral load set point has significantly increased at a population level. Here we studied...
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