Article
[Modified Restriction Enzyme-based Detection of EGFR Mutations in Lung Cancer].
Zhongguo fei ai za zhi = Chinese journal of lung cancer - 1 Aug 2011
Yang Fan, Chen Kezhong, Jiang Guanchao, Li Jianfeng, Wang Jun
Abstract excerpt
BACKGROUND: Epidermal growth factor receptor (EGFR) gene mutation in lung cancer is a reliable predictor of the efficacy of tyrosine kinase inhibitors, so detection of gene mutation has very important clinical significance. The aim of this study is to optimize conditions for restriction enzyme-based mutant enriched detection of EGFR mutation in lung cancer specimens. METHODS: EGFR somatic mutations identified in...
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