Article
A reassessment of methylcholanthrene transformation in the C3H10T1/2 cell culture system.
Carcinogenesis - 1 May 1990
Chen A C, Brankow D W, Herschman H R
Abstract excerpt
We previously demonstrated that four tumorigenic methylcholanthrene (MCA) transformed cell lines derived from C3H10T1/2 cells each contain a common G34----T nucleotide alteration in the c-Ki-ras gene. In contrast, a non-tumorigenic MCA transformant does not contain this mutation. We have now exam...
Topics
- Animals
- Cell Division
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- DNA
- Genes, ras
- Guanine
- Methylcholanthrene
- Mice
- Mutation
- Thymine