Article
Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination.
Cell - 4 May 1990
Alani E, Padmore R, Kleckner N
Abstract excerpt
The RAD50 gene of S. cerevisiae is required during meiosis for both recombination and chromosome synapsis and is also required for repair of double strand breaks during vegetative growth. We present below the isolation and analysis of several types of rad50 mutants. We show that null mutations block both meiotic recombination and formation of synaptonemal complex (SC) at early stages, while nonnull mutations...
Read the complete abstract on PubMedTopics
- Amino Acid Sequence
- Base Sequence
- Blotting, Southern
- Cell Nucleus
- Chromosome Deletion
- Chromosomes, Fungal
- DNA, Fungal