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Article

The sep1 mutant of Saccharomyces cerevisiae arrests in pachytene and is deficient in meiotic recombination.

Genetics - 1 Feb 1995

Tishkoff D X, Rockmill B, Roeder G S, Kolodner R D

Abstract excerpt

Strand exchange protein 1 (Sep1) from Saccharomyces cerevisiae promotes homologous pairing of DNA in vitro and sep1 mutants display pleiotropic phenotypes in both vegetative and meiotic cells. In this study, we examined in detail the ability of the sep1 mutant to progress through meiosis I prophase and to undergo meiotic recombination. In meiotic return-to-growth experiments, commitment to meiotic recombination...

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Identifiers

PMID: 7713413
DOI: 10.1093/genetics/139.2.495
PMCID: PMC1206362

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