Article
Coprinus cinereus rad50 mutants reveal an essential structural role for Rad50 in axial element and synaptonemal complex formation, homolog pairing and meiotic recombination.
Genetics - 1 Dec 2008
Acharya Sonia N, Many Alexander M, Schroeder Andrew P, Kennedy Felicia M, Savytskyy Oleksandr P, Grubb Jennifer T, Vincent Jack A, Friedle Elizabeth A, Celerin Martina, Maillet Daniel S, Palmerini Heather J, Greischar Megan A, Moncalian Gabriel, Williams R Scott, Tainer John A, Zolan Miriam E
Abstract excerpt
The Mre11/Rad50/Nbs1 (MRN) complex is required for eukaryotic DNA double-strand break (DSB) repair and meiotic recombination. We cloned the Coprinus cinereus rad50 gene and showed that it corresponds to the complementation group previously named rad12, identified mutations in 15 rad50 alleles, and mapped two of the mutations onto molecular models of Rad50 structure. We found that C. cinereus rad50 and mre11...
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