cis-syn thymine dimers are not absolute blocks to replication by DNA polymerase I of Escherichia coli in vitro.

doi:10.1021/bi00458a038

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Article

cis-syn thymine dimers are not absolute blocks to replication by DNA polymerase I of Escherichia coli in vitro.

Biochemistry - 13 Feb 1990

Taylor J S, O'Day C L

Abstract excerpt

Both Escherichia coli DNA polymerase I (pol I) and the large fragment of pol I (Klenow) were found to bypass a site-specific cis-syn thymine dimer, in vitro, under standard conditions. A template was constructed by ligating d(pCGTAT[c,s]TATGC), synthesized via a cis-syn thymine dimer phosphoramid...

Topics

Base Sequence
DNA Polymerase I
DNA Replication
Escherichia coli
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides
Pyrimidine Dimers
Templates, Genetic

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