Article
Synthesis and characterization of a [3-15N]-labeled cis-syn thymine dimer-containing DNA duplex.
The Journal of organic chemistry - 17 Feb 2006
Bdour Hussam M, Kao Jeff Lung-Fa, Taylor John-Stephen
Abstract excerpt
Cis-syn thymine dimers are the major photoproducts of DNA and are the principal cause of mutations induced by sunlight. To better understand the nature of base pairing with cis-syn thymine dimers, we have synthesized a decamer oligodeoxynucleotide (ODN) containing a cis-syn thymine dimer labeled at the N3 of both T's with 15N by two efficient routes from [3-15N]-thymidine phosphoramidite. In the postsynthetic...
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