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Article

Measuring the fidelity of translesion DNA synthesis.

Methods in enzymology - 1 Jan 2006

McCulloch Scott D, Kunkel Thomas A

Abstract excerpt

A method is described to measure the fidelity of copying past a DNA lesion in a defined sequence on a synthetic oligonucleotide primer-template. The DNA product is the result of a complete lesion bypass reaction, i.e., containing all four deoxynucleotide triphosphates and requiring both insertion opposite the lesion and multiple extensions from the resulting primer termini containing the lesion. The nascent...

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PMID: 16793379
DOI: 10.1016/S0076-6879(06)08021-9

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