Article
In vivo evidence that UV-induced C-->T mutations at dipyrimidine sites could result from the replicative bypass of cis-syn cyclobutane dimers or their deamination products.
Biochemistry - 19 Jan 1993
Jiang N, Taylor J S
Abstract excerpt
The major mutations induced by UV light are C-->T transitions at dipyrimidines and arise from the incorporation of A opposite the C of dipyrimidine photoproducts. The incorporation of A has most often been explained by the known preference of a polymerase to do so opposite noninstructional DNA da...
Topics
- Amination
- Bacteriophages
- Base Sequence
- Cystine
- DNA Replication
- DNA, Bacterial
- Deamination
- Escherichia coli
- Molecular Sequence Data
- Mutation
- Photochemistry
- Pyrimidine Dimers
- SOS Response, Genetics
- Thymidine
- Ultraviolet Rays