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Article

Angiotensin II activates AMPK for execution of apoptosis through energy-dependent and -independent mechanisms.

American journal of physiology. Lung cellular and molecular physiology - 1 Nov 2011

Day Regina M, Lee Young H, Han Li, Kim Yong-Chul, Feng Ying-Hong

Abstract excerpt

At the cellular level, 5'-AMP-activated protein kinase (AMPK) serves as a critical link between energy homeostasis and the regulation of fundamental biological activities, including apoptosis. Angiotensin (Ang) II plays a key role in fibrotic lung remodeling. We recently demonstrated that Ang II induces apoptosis in pulmonary artery endothelial cells (PAEC) through the Ang type 2 receptor (AT(2)). AT(2) activates...

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Identifiers

PMID: 21856818
DOI: 10.1152/ajplung.00072.2011
PMCID: PMC3213991

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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