Article
A new constitutively active mutant of AMP-activated protein kinase inhibits anoxia-induced apoptosis of vascular endothelial cell.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Feb 2009
Nagata Daisuke, Kiyosue Arihiro, Takahashi Masao, Satonaka Hiroshi, Tanaka Kimie, Sata Masataka, Nagano Tetsuo, Nagai Ryozo, Hirata Yasunobu
Abstract excerpt
The inhibition of apoptotic changes in vascular endothelial cells is important for preventing vascular damage from hypoxia. AMP-activated protein kinase (AMPK) has recently been identified as playing a role in vascular protection. Although the chemical reagent 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) has been used to stimulate AMPK activity, AICAR has been associated with several nonspecific...
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