Article
Detection of Novel Amino Acid Polymorphisms in the East Asian CagA of Helicobacter Pylori with Full Sequencing Data.
The Kobe journal of medical sciences - 8 Jun 2020
Hayashi Hiroki, Inoue Jun, Oyama Katsuaki, Matsuoka Koki, Nishiumi Shin, Yoshida Masaru, Yano Yoshihiko, Kodama Yuzo
Abstract excerpt
Cytotoxin-associated gene A (CagA) is generally accepted to be the most important virulence factor of Helicobacter pylori and increases the risk of developing gastric cancer. East Asian CagA, which includes the EPIYA-D segment at the C-terminal region, has a significantly higher gastric carcinogenic rate than Western CagA including the EPIYA-C segment. Although the amino acid polymorphism surrounding the EPIYA...
Topics
- Antigens, Bacterial
- Bacterial Proteins
- Databases, Genetic
- Asia, Eastern
- Helicobacter pylori
- Japan
- Polymorphism, Single Nucleotide
- Virulence Factors
- Whole Genome Sequencing