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Article

Influence of EPIYA-repeat polymorphism on the phosphorylation-dependent biological activity of Helicobacter pylori CagA.

Gastroenterology - 1 Apr 2006

Naito Masanori, Yamazaki Takeshi, Tsutsumi Ryouhei, Higashi Hideaki, Onoe Kazunori, Yamazaki Shiho, Azuma Takeshi, Hatakeyama Masanori

Abstract excerpt

BACKGROUND & AIMS: Helicobacter pylori CagA-positive strain is associated with gastric adenocarcinoma. CagA is delivered into gastric epithelial cells, where it undergoes tyrosine phosphorylation at the EPIYA sites by Src family kinases (SFKs). Owing to homologous recombination within the 3'-region of the cagA gene, 4 distinct EPIYA sites, each of which is defined by surrounding sequences, are variably assembled...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

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Share to Repetitive Sequences, Amino Acid

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Source

Identifiers

PMID: 16618412
DOI: 10.1053/j.gastro.2005.12.038

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Influence of EPIYA-repeat polymorphism on the phosphorylation-dependent biological activity of Helicobacter pylori CagA.PMID 16618412Read ↗

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