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Article

TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68.

The Journal of biological chemistry - 4 Mar 2005

Wei Jen-Hsuan, Chou Yi-Fan, Ou Yi-Hung, Yeh Yen-Hsiu, Tyan Shiaw-Wei, Sun Te-Ping, Shen Chen-Yang, Shieh Sheau-Yann

Abstract excerpt

CHK2/hCds1 plays important roles in the DNA damage-induced cell cycle checkpoint by phosphorylating several important targets, such as Cdc25 and p53. To obtain a better understanding of the CHK2 signaling pathway, we have carried out a yeast two-hybrid screen to search for potential CHK2-interacting proteins. Here, we report the identification of the mitotic checkpoint kinase, TTK/hMps1, as a novel...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15618221
DOI: 10.1074/jbc.M410152200

Genes

TTK

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68.PMID 15618221Read ↗

A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1Semantic proximity Read ↗

The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation.Semantic proximity Read ↗

Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.Semantic proximity Read ↗

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MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways.Semantic proximity Read ↗

Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis.Semantic proximity Read ↗

Chk1 Inhibitors for Novel Cancer TreatmentSemantic proximity Read ↗

Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain.Semantic proximity Read ↗

Specific role of Chk1 phosphorylations in cell survival and checkpoint activation.Semantic proximity Read ↗

Stability of checkpoint kinase 2 is regulated via phosphorylation at serine 456.Semantic proximity Read ↗

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