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Article

Sickle cell trait is not independently associated with susceptibility to end-stage renal disease in African Americans.

Kidney international - 1 Dec 2011

Hicks Pamela J, Langefeld Carl D, Lu Lingyi, Bleyer Anthony J, Divers Jasmin, Nachman Patrick H, Derebail Vimal K, Bowden Donald W, Freedman Barry I

Abstract excerpt

Conflicting reports exist as to whether sickle cell trait is a risk factor for the progression of nephropathy. In order to determine whether African Americans with sickle cell trait are at increased risk for kidney disease, we assessed the genetic association between sickle cell trait and end-stage renal disease (ESRD). Hemoglobin S, non-muscle myosin heavy chain 9 (MYH9), and apolipoprotein L1 (APOL1) risk...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21849968
DOI: 10.1038/ki.2011.286
PMCID: PMC3280424

Genes

APOL1
MYH9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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