Article
MYH9 is associated with nondiabetic end-stage renal disease in African Americans.
Nature genetics - 1 Oct 2008
Kao W H Linda, Klag Michael J, Meoni Lucy A, Reich David, Berthier-Schaad Yvette, Li Man, Coresh Josef, Patterson Nick, Tandon Arti, Powe Neil R, Fink Nancy E, Sadler John H, Weir Matthew R, Abboud Hanna E, Adler Sharon G, Divers Jasmin, Iyengar Sudha K, Freedman Barry I, Kimmel Paul L, Knowler William C, Kohn Orly F, Kramp Kristopher, Leehey David J, Nicholas Susanne B, Pahl Madeleine V, Schelling Jeffrey R, Sedor John R, Thornley-Brown Denyse, Winkler Cheryl A, Smith Michael W, Parekh Rulan S
Abstract excerpt
As end-stage renal disease (ESRD) has a four times higher incidence in African Americans compared to European Americans, we hypothesized that susceptibility alleles for ESRD have a higher frequency in the West African than the European gene pool. We carried out a genome-wide admixture scan in 1,372 ESRD cases and 806 controls and found a highly significant association between excess African ancestry and...
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