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Article

Differential effects of MYH9 and APOL1 risk variants on FRMD3 Association with Diabetic ESRD in African Americans.

PLoS genetics - 1 Jun 2011

Freedman Barry I, Langefeld Carl D, Lu Lingyi, Divers Jasmin, Comeau Mary E, Kopp Jeffrey B, Winkler Cheryl A, Nelson George W, Johnson Randall C, Palmer Nicholette D, Hicks Pamela J, Bostrom Meredith A, Cooke Jessica N, McDonough Caitrin W, Bowden Donald W

Abstract excerpt

Single nucleotide polymorphisms (SNPs) in MYH9 and APOL1 on chromosome 22 (c22) are powerfully associated with non-diabetic end-stage renal disease (ESRD) in African Americans (AAs). Many AAs diagnosed with type 2 diabetic nephropathy (T2DN) have non-diabetic kidney disease, potentially masking detection of DN genes. Therefore, genome-wide association analyses were performed using the Affymetrix SNP Array 6.0 in...

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Share to Apolipoprotein L1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 22

Share to Diabetic Nephropathies

Share to Kidney Failure, Chronic

Share to Lipoproteins, HDL

Share to Molecular Motor Proteins

Share to Myosin Heavy Chains

Source

Open in PubMed Open full text

Identifiers

PMID: 21698141
DOI: 10.1371/journal.pgen.1002150
PMCID: PMC3116917

Genes

FRMD3
MYH9
APOL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

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Differential effects of MYH9 and APOL1 risk variants on FRMD3 Association with Diabetic ESRD in African Americans.PMID 21698141Read ↗

Evaluation of candidate nephropathy susceptibility genes in a genome-wide association study of African American diabetic kidney disease.Semantic proximity Read ↗

Polymorphisms in MYH9 are associated with diabetic nephropathy in European Americans.Semantic proximity Read ↗

Non-muscle myosin heavy chain 9 gene MYH9 associations in African Americans with clinically diagnosed type 2 diabetes mellitus-associated ESRD.Semantic proximity Read ↗

Candidate genes for non-diabetic ESRD in African Americans: a genome-wide association study using pooled DNA.Semantic proximity Read ↗

The apolipoprotein L1 (APOL1) gene and nondiabetic nephropathy in African Americans.Semantic proximity Read ↗

MYH9 is associated with nondiabetic end-stage renal disease in African Americans.Semantic proximity Read ↗

African ancestry allelic variation at the MYH9 gene contributes to increased susceptibility to non-diabetic end-stage kidney disease in Hispanic Americans.Semantic proximity Read ↗

Genome-wide association study identifies novel loci for type 2 diabetes-attributed end-stage kidney disease in African AmericansSemantic proximity Read ↗

Re-Sequencing of the APOL1-APOL4 and MYH9 Gene Regions in African Americans Does Not Identify Additional Risks for CKD Progression.Semantic proximity Read ↗

The MYH9/APOL1 region and chronic kidney disease in European-Americans.Semantic proximity Read ↗

Analysis of coding variants identified from exome sequencing resources for association with diabetic and non-diabetic nephropathy in African Americans.Semantic proximity Read ↗

Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene.Semantic proximity Read ↗

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