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Article

MYH9 and APOL1 are both associated with sickle cell disease nephropathy.

British journal of haematology - 1 Nov 2011

Ashley-Koch Allison E, Okocha Emmanuel C, Garrett Melanie E, Soldano Karen, De Castro Laura M, Jonassaint Jude C, Orringer Eugene P, Eckman James R, Telen Marilyn J

Abstract excerpt

Renal failure occurs in 5-18% of sickle cell disease (SCD) patients and is associated with early mortality. At-risk SCD patients cannot be identified prior to the appearance of proteinuria and the pathobiology is not well understood. The myosin, heavy chain 9, non-muscle (MYH9) and apolipoprotein L1 (APOL1) genes have been associated with risk for focal segmental glomerulosclerosis and end-stage renal disease in...

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Share to Aged, 80 and over
Share to Anemia, Sickle Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoprotein L1

Share to Apolipoproteins

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Share to Lipoproteins, HDL

Share to Molecular Motor Proteins

Share to Myosin Heavy Chains

Source

Open in PubMed Open full text

Identifiers

PMID: 21910715
DOI: 10.1111/j.1365-2141.2011.08832.x
PMCID: PMC3885232

Genes

APOL1
MYH9
SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MYH9 and APOL1 are both associated with sickle cell disease nephropathy.PMID 21910715Read ↗

Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene.Semantic proximity Read ↗

The spectrum of MYH9-associated nephropathy.Semantic proximity Read ↗

Polymorphisms in MYH9 are associated with diabetic nephropathy in European Americans.Semantic proximity Read ↗

Apolipoprotein L1 gene variants associate with hypertension-attributed nephropathy and the rate of kidney function decline in African Americans.Semantic proximity Read ↗

Non-muscle myosin heavy chain 9 gene MYH9 associations in African Americans with clinically diagnosed type 2 diabetes mellitus-associated ESRD.Semantic proximity Read ↗

Polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) are associated with albuminuria in hypertensive African Americans: the HyperGEN study.Semantic proximity Read ↗

The apolipoprotein L1 (APOL1) gene and nondiabetic nephropathy in African Americans.Semantic proximity Read ↗

MYH9 genetic variants associated with glomerular disease: what is the role for genetic testing?Semantic proximity Read ↗

Systematic Review of Genetic Modifiers Associated with the Development and/or Progression of Nephropathy in Patients with Sickle Cell Disease.Semantic proximity Read ↗

KIDNEY DISEASE GENETICS AND THE IMPORTANCE OF DIVERSITY IN PRECISION MEDICINE.Semantic proximity Read ↗

MYH9 E1841K Mutation Augments Proteinuria and Podocyte Injury and Migration.Semantic proximity Read ↗

Potential effects of MYH9-associated nephropathy on dialysis and kidney transplant outcomes.Semantic proximity Read ↗

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