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Article

Mechanisms of increased risk of tumorigenesis in Atm and Brca1 double heterozygosity.

Radiation oncology (London, England) - 17 Aug 2011

Wang Jufang, Su Fengtao, Smilenov Lubomir B, Zhou Libin, Hu Wentao, Ding Nan, Zhou Guangming

Abstract excerpt

BACKGROUND: Both epidemiological and experimental studies suggest that heterozygosity for a single gene is linked with tumorigenesis and heterozygosity for two genes increases the risk of tumor incidence. Our previous work has demonstrated that Atm/Brca1 double heterozygosity leads to higher cell transformation rate than single heterozygosity. However, the underlying mechanisms have not been fully understood yet....

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Identifiers

PMID: 21849032
DOI: 10.1186/1748-717X-6-96
PMCID: PMC3169458

Genes

ATM
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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