Article
Increased Radiosensitivity of Solid Tumors Harboring ATM and BRCA1/2 Mutations.
Cancer research and treatment - 1 Jan 2022
Kim Kyung Hwan, Kim Han Sang, Kim Seung-Seob, Shim Hyo Sup, Yang Andrew Jihoon, Lee Jason Joon Bock, Yoon Hong In, Ahn Joong Bae, Chang Jee Suk
Abstract excerpt
PURPOSE: Preclinical data indicate that response to radiotherapy (RT) depends on DNA damage repair. In this study, we investigated the role of mutations in genes related to DNA damage repair in treatment outcome after RT. MATERIALS AND METHODS: Patients with solid tumor who participated in next generation sequencing panel screening using biopsied tumor tissue between October 2013 and February 2019 were reviewed...
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