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A pleiotropic ATM variant (rs1800057 C>G) is associated with risk of multiple cancers.

Carcinogenesis - 11 Feb 2022

Qian Danwen, Liu Hongliang, Zhao Lingling, Luo Sheng, Walsh Kyle M, Huang Jiaoti, Li Chuan-Yuan, Wei Qingyi

Abstract excerpt

ATM (ataxia-telangiectasia mutated) is an important cell-cycle checkpoint kinase required for cellular response to DNA damage. Activated by DNA double strand breaks, ATM regulates the activities of many downstream proteins involved in various carcinogenic events. Therefore, ATM or its genetic variants may have a pleiotropic effect on cancer development. We conducted a pleiotropic analysis to evaluate associations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34643693
DOI: 10.1093/carcin/bgab092
PMCID: PMC8832460

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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