Article

Coinheritance of pathogenic variants in ATM and BRCA2 in families with multiple cancers: a case series

2022-09-30

Abstract excerpt

<h4>Purpose: </h4> Pathogenic variants (PVs) in BRCA2 and ATM genes have been linked to an increased risk of various cancers. BRCA2 and ATM are part of the homologous recombination pathway, but the tumor risk in patients with simultaneous PVs in both genes remains largely unknown. In this study we describe four patients from three families with multiple cancers who coinherited PVs in BRCA2 and ATM genes. <h4>Metho...

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Literature Corpus work: c9a6c898-d0a0-51c8-aa44-b16668999d0d
DOI: 10.21203/rs.3.rs-2112256/v1

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