Risk of cancer by ATM missense mutations in the general population.

doi:10.1200/JCO.2007.14.6613

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

Risk of cancer by ATM missense mutations in the general population.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Jun 2008

Dombernowsky Sarah Louise, Weischer Maren, Allin Kristine Højgaard, Bojesen Stig Egil, Tybjaerg-Hansen Anne, Nordestgaard Børge Grønne

Abstract excerpt

PURPOSE: Truncating and missense mutations in the ATM gene, which cause insufficient DNA damage surveillance, allow damaged cells to proceed into mitosis, which eventually results in increased cancer susceptibility. We tested the hypotheses that ATM Ser49Cys and ATM Ser707Pro heterozygosity increase the risk of cancer overall, of breast cancer, and of 26 other cancer subtypes in the general population. PATIENTS...

Topics

Adult
Ataxia Telangiectasia Mutated Proteins
Breast Neoplasms
Cell Cycle Proteins
DNA-Binding Proteins
Denmark
Female
Genetic Predisposition to Disease
Heterozygote
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Mutation, Missense

Neoplasms

Prospective Studies

Protein Serine-Threonine Kinases

Tumor Suppressor Proteins

Source

Open in PubMed

Identifiers

PMID: 18565893
DOI: 10.1200/JCO.2007.14.6613

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Risk of cancer by ATM missense mutations in the general population.PMID 18565893Read ↗

Cancer risks associated with heterozygous ATM loss of function and missense pathogenic variants based on multigene panel analysis.Semantic proximity Read ↗

Cancer risks and mortality in heterozygous ATM mutation carriers.Semantic proximity Read ↗

Germline Pathogenic Variants in the Ataxia Telangiectasia Mutated (ATM) Gene are Associated with High and Moderate Risks for Multiple Cancers.Semantic proximity Read ↗

Missense variants in ATM in 26,101 breast cancer cases and 29,842 controls.Semantic proximity Read ↗

Population-based estimates of age-specific cumulative risk of breast cancer for pathogenic variants in ATM.Semantic proximity Read ↗

Rare variants in the ATM gene and risk of breast cancer.Semantic proximity Read ↗

Cancer risks for ATM variant heterozygotes.Semantic proximity Read ↗

Ataxia-telangiectasia gene (ATM) mutation heterozygosity in breast cancer: a narrative review.Semantic proximity Read ↗

Uncovering variable neoplasms between ATM protein-truncating and common missense variants using 394 694 UK Biobank exomes.Semantic proximity Read ↗

ATM: Functions of ATM Kinase and Its Relevance to Hereditary Tumors.Semantic proximity Read ↗

Variants in the ATM gene associated with a reduced risk of contralateral breast cancer.Semantic proximity Read ↗

Penetrance of ATM Gene Mutations in Breast Cancer: A Meta-Analysis of Different Measures of Risk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.