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Article

Association of common ATM polymorphism with bilateral breast cancer.

International journal of cancer - 10 Aug 2005

Heikkinen Katri, Rapakko Katrin, Karppinen Sanna-Maria, Erkko Hannele, Nieminen Pentti, Winqvist Robert

Abstract excerpt

The ATM kinase has an essential role in maintaining genomic integrity. Loss of both ATM alleles results in ataxia-telangiectasia (A-T), a rare autosomal recessive neuroimmunologic disorder associated with cancer susceptibility. Individuals heterozygous for germline ATM mutations have been reported to have an increased risk for malignancy, in particular, female breast cancer. In the current study, a full mutation...

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Source

Identifiers

PMID: 15756685
DOI: 10.1002/ijc.20996

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Association of common ATM polymorphism with bilateral breast cancer.PMID 15756685Read ↗

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Association of common ATM variants with familial breast cancer in a South American population.Semantic proximity Read ↗

Single nucleotide polymorphism D1853N of the ATM gene may alter the risk for breast cancer.Semantic proximity Read ↗

ATM variants 7271T>G and IVS10-6T>G among women with unilateral and bilateral breast cancer.Semantic proximity Read ↗

Whole genome joint analysis reveals ATM:C.1564_1565del variant segregating with Ataxia-Telangiectasia and breast cancer.Semantic proximity Read ↗

Radiation exposure, the ATM Gene, and contralateral breast cancer in the women's environmental cancer and radiation epidemiology study.Semantic proximity Read ↗

[Ataxia-telangiectasia mutated gene and breast cancer susceptibility].Semantic proximity Read ↗

The association between ATM variants and risk of breast cancer: a systematic review and meta-analysis.Semantic proximity Read ↗

Association between polymorphisms of the ataxia telangiectasia mutated gene and breast cancer risk: evidence from the current studies.Semantic proximity Read ↗

ATM and breast cancer susceptibility.Semantic proximity Read ↗

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