Article
Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas.
Acta neuropathologica - 1 Dec 2010
Hartmann Christian, Hentschel Bettina, Wick Wolfgang, Capper David, Felsberg Jörg, Simon Matthias, Westphal Manfred, Schackert Gabriele, Meyermann Richard, Pietsch Torsten, Reifenberger Guido, Weller Michael, Loeffler Markus, von Deimling Andreas
Abstract excerpt
WHO grading of human brain tumors extends beyond a strictly histological grading system by providing a basis predictive for the clinical behavior of the respective neoplasm. For example, patients with glioblastoma WHO grade IV usually show a less favorable clinical course and receive more aggressive first-line treatment than patients with anaplastic astrocytoma WHO grade III. Here we provide evidence that the...
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