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Article

Diffuse gliomas in patients aged 55 years or over: A suggestion for IDH mutation testing.

Neuropathology : official journal of the Japanese Society of Neuropathology - 1 Feb 2020

Barresi Valeria, Eccher Albino, Simbolo Michele, Cappellini Rekha, Ricciardi Giuseppe K, Calabria Francesca, Cancedda Marco, Mazzarotto Renzo, Bonetti Bruno, Pinna Giampietro, Sala Francesco, Ghimenton Claudio, Scarpa Aldo

Abstract excerpt

Diffuse gliomas are defined on the isocitrate dehydrogenase (IDH) gene (IDH) mutational mutational status. The most frequent IDH mutation is IDH1 R132H, which is detectable by immunohistochemistry; other IDH mutations are rare (10%). IDH mutant gliomas have better prognosis. Further, IDH wild-type low-grade (II/III) gliomas have clinical behaviors similar to those of glioblastoma (GBM) and it was suggested that...

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Identifiers

PMID: 31758617
DOI: 10.1111/neup.12608

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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