Genetic variation and haplotype structures of the glutathione S-transferase genes GSTA1 and GSTA2 in Japanese colorectal cancer patients.

doi:10.2133/dmpk.DMPK-11-SC-050

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Article

Genetic variation and haplotype structures of the glutathione S-transferase genes GSTA1 and GSTA2 in Japanese colorectal cancer patients.

Drug metabolism and pharmacokinetics - 1 Jan 2011

Maekawa Keiko, Hamaguchi Tetsuya, Saito Yoshiro, Tatewaki Naoko, Kurose Kouichi, Kaniwa Nahoko, Eguchi Nakajima Takako, Kato Ken, Yamada Yasuhide, Shimada Yasuhiro, Yoshida Teruhiko, Kamatani Naoyuki, Ura Takashi, Saito Miyuki, Muro Kei, Fuse Nozomu, Yoshino Takayuki, Doi Toshihiko, Otsu Atsushi, Saijo Nagahiro, Sawada Jun-Ichi, Okuda Haruhiro, Matsumura Yasuhiro

Abstract excerpt

Glutathione S-transferases (GSTs) play a vital role in the phase II biotransformation of many chemicals, including anticancer drugs. In this study, to elucidate the haplotype structures of the two closely related alpha-class genes GSTA1 and GSTA2, we screened for genetic variation in 214 Japanese colorectal cancer patients who received oxaliplatin-based chemotherapy. By direct resequencing of the 5'-flanking...

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PMID: 21844655
DOI: 10.2133/dmpk.DMPK-11-SC-050

Genes

GSTA2
GSTA1

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