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Article

The effect of UGT1A and UGT2B polymorphisms on colorectal cancer risk: haplotype associations and gene–environment interactions.

Genes, chromosomes & cancer - 1 Jun 2014

Angstadt Andrea Y, Hartman Terryl J, Lesko Samuel M, Muscat Joshua E, Zhu Junjia, Gallagher Carla J, Lazarus Philip

Abstract excerpt

UDP-glucuronosyltransferases (UGTs) play an important role in the phase II metabolism of exogenous and endogenous compounds. As colorectal cancer (CRC) etiology is thought to involve the biotransformation of dietary factors, UGT polymorphisms may affect CRC risk by altering levels of exposure. Genotyping of over 1800 Caucasian subjects was completed to identify the role of genetic variation in nine UGT1A and five...

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Source

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Identifiers

PMID: 24822274
DOI: 10.1002/gcc.22157
PMCID: PMC4048880

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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