Article
Microsomal glutathione S-transferase gene polymorphisms and colorectal cancer risk in a Han Chinese population.
International journal of colorectal disease - 1 Oct 2007
Zhang Hao, Liao Ling-Hong, Liu Shuk-Ming, Lau Kwok-Wai, Lai Albert Kai-Cheong, Zhang Jin-Hui, Wang Qi, Chen Xiao-Qian, Wei Wei, Liu Hua, Cai Jian-Hua, Lung Maria Li, Tai Susan S W, Wu Madeline
Abstract excerpt
BACKGROUND AND AIMS: Glutathione S-transferases (GSTs) are phase II detoxification enzymes. Human GSTs have been classified into cytosolic, mitochondrial, and microsomal families. Several studies reported the association of colorectal cancer (CRC) risk with the genetic polymorphisms of cytosolic GSTs. The microsomal GSTs are structurally distinct but functionally similar to cytosolic GSTs; their association with...
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