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Article

CKIT mutation in therapy-related acute myeloid leukemia with MLLT3/MLL chimeric transcript from t(9;11)(p22;q23).

Annals of clinical and laboratory science - 1 Jan 2011

Jung Chae Lim, Kim Hee-Jin, Kim Dong-Hwan, Huh Heejae, Song Min-Jung, Kim Sun-Hee

Abstract excerpt

Gain-of-function mutations of the CKIT gene have been reported to specifically occur in core-binding factor (CBF) acute myeloid leukemia (AML) with a poor prognostic implication. Here we report a case of therapy-related AML with t(9;11)(p22;q23) who had CKIT mutation. A 48-year-old woman with breast cancer received partial mastectomy followed by 6 cycles of adjuvant chemotherapy and radiation therapy. At 28...

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Share to Chromosomes, Human, Pair 11
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone-Lysine N-Methyltransferase

Share to Leukemia, Myeloid, Acute

Share to Myeloid-Lymphoid Leukemia Protein

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Share to Proto-Oncogene Proteins c-kit

Share to Translocation, Genetic

Source

Identifiers

PMID: 21844580

Genes

MLLT3
FLT3
NPM1

Variants

Provenance

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