Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of a novel type of KMT2A/EPS15 fusion transcript in FLT3 mutation-positive B-lymphoblastic leukemia with t(1;11)(p32;q23).

Cancer genetics - 1 Jun 2021

Yamamoto Katsuya, Yakushijin Kimikazu, Mizutani Yu, Okuni-Watanabe Marika, Goto Hideaki, Higashime Ako, Miyata Yoshiharu, Kitao Akihito, Matsumoto Hisayuki, Saegusa Jun, Matsuoka Hiroshi, Minami Hironobu

Abstract excerpt

The t(1;11)(p32;q23) translocation is a rare but recurrent cytogenetic aberration in acute myeloid leukemia (AML) and B-cell acute lymphoblastic leukemia (B-ALL). This translocation was initially shown to form a fusion gene between KMT2A exon 8 at 11q23 and EPS15 exon 2 at 1p32 in AML. Activating mutations of FLT3 are frequently found in AML but are very rare in ALL. Here, we describe a 75-year-old woman who was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow Cells
Share to Cell Shape

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 1

Share to Chromosomes, Human, Pair 11

Share to Fatal Outcome

Share to fms-Like Tyrosine Kinase 3

Share to Oncogene Proteins, Fusion

Share to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

Source

Identifiers

PMID: 33647817
DOI: 10.1016/j.cancergen.2021.02.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of a novel type of KMT2A/EPS15 fusion transcript in FLT3 mutation-positive B-lymphoblastic leukemia with t(1;11)(p32;q23).PMID 33647817Read ↗

A new variant of KMT2A(MLL)-FLNA fusion transcript in acute myeloid leukemia with ins(X;11)(q28;q23q23).Semantic proximity Read ↗

Molecular characteristic of acute leukemias with t(16;21)/FUS-ERG.Semantic proximity Read ↗

NUP98 is fused to HOXA9 in a variant complex t(7;11;13;17) in a patient with AML-M2.Semantic proximity Read ↗

Two rare cases of acute myeloid leukemia with t(8;16)(p11.2;p13.3) and 1q duplication: case presentation and literature reviewSemantic proximity Read ↗

A rare cytogenetic presentation of acute myeloid leukemia (AML-M2).Semantic proximity Read ↗

CKIT mutation in therapy-related acute myeloid leukemia with MLLT3/MLL chimeric transcript from t(9;11)(p22;q23).Semantic proximity Read ↗

Lineage Switch in an Infant B-Lymphoblastic Leukemia With t(1;11)(p32;q23); KMT2A/EPS15 , Following Blinatumomab TherapySemantic proximity Read ↗

AML1-ETO9a is correlated with C-KIT overexpression/mutations and indicates poor disease outcome in t(8;21) acute myeloid leukemia-M2.Semantic proximity Read ↗

Identification of four new translocations involving FGFR1 in myeloid disordersSemantic proximity Read ↗

Translocation (8;18;16)(p11;q21;p13). A new variant of t(8;16)(p11;p13) in acute monoblastic leukemia: case report and review of the literature.Semantic proximity Read ↗

NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15)Semantic proximity Read ↗

Consistent detection of TLS/FUS-ERG chimeric transcripts in acute myeloid leukemia with t(16;21)(p11;q22) and identification of a novel transcript.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.