Article
Prognostic impact of c-KIT mutations in core binding factor leukemias: an Italian retrospective study.
Blood - 1 May 2006
Cairoli Roberto, Beghini Alessandro, Grillo Giovanni, Nadali Gianpaolo, Elice Francesca, Ripamonti Carla Barbara, Colapietro Patrizia, Nichelatti Michele, Pezzetti Laura, Lunghi Monia, Cuneo Antonio, Viola Assunta, Ferrara Felicetto, Lazzarino Mario, Rodeghiero Francesco, Pizzolo Giovanni, Larizza Lidia, Morra Enrica
Abstract excerpt
Distinct forms of tyrosine kinase domain (TKD), juxtamembrane domain, exon 8, and internal tandem duplication (ITD) mutations of c-KIT, were observed in about 46% of core binding factor leukemia (CBFL) patients. To evaluate their prognostic significance, 67 adult patients with CBFL were analyzed to ascertain the c-KIT mutation status. In acute myeloid leukemia (AML) with t(8;21), the presence of c-KIT TKD...
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