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Article

Effects of c-KIT mutations on expression of the RUNX1/RUNX1T1 fusion transcript in t(8;21)-positive acute myeloid leukemia patients.

Leukemia research - 1 Jul 2013

Park Sang Hyuk, Chi Hyun-Sook, Cho Young-Uk, Jang Seongsoo, Park Chan-Jeoung

Abstract excerpt

The aim of this study was to evaluate effect of c-KIT mutations on RUNX1/RUNX1T1 fusion transcript expression in patients with t(8;21)-positive AML. Fifty patients diagnosed with t(8;21)-positive AML for recent 10 years were enrolled. Patients with c-KIT mutations tended to achieve a greater than 3-log reduction in RUNX1/RUNX1T1 fusion transcript expression less frequently than patients without mutations from 6...

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Share to Chromosomes, Human, Pair 21
Share to Chromosomes, Human, Pair 8

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Core Binding Factor Alpha 2 Subunit

Share to Neoplasm Recurrence, Local

Share to Oncogene Proteins, Fusion

Share to Proto-Oncogene Proteins c-kit

Share to RUNX1 Translocation Partner 1 Protein

Share to Translocation, Genetic

Source

Identifiers

PMID: 23528260
DOI: 10.1016/j.leukres.2013.02.010

Genes

KIT
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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