Article
A new variant of KMT2A(MLL)-FLNA fusion transcript in acute myeloid leukemia with ins(X;11)(q28;q23q23).
Cancer genetics - 1 Apr 2015
Matveeva Elena, Kazakova Anna, Olshanskaya Yulia, Tsaur Grigory, Shelikhova Larisa, Meyer Claus, Marschalek Rolf, Novichkova Galina, Maschan Michael, Maschan Aleksey
Abstract excerpt
The KMT2A gene (previously known as MLL) located at 11q23 is often involved in recurrent chromosomal translocations that lead to the development of acute leukemia, particularly in infants. Acute leukemias with KMT2A rearrangements have different prognoses, which depend on the partner gene involved in the translocation. The detection of all possible types of KMT2A gene rearrangements is of key importance for the...
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