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Article

Molecular classification of mucoepidermoid carcinomas—Prognostic significance of the <i>MECT1</i> – <i>MAML2</i> fusion oncogene

27 Jan 2006

Abstract excerpt

Mucoepidermoid carcinomas (MECs) of the salivary and bronchial glands are characterized by a recurrent t(11;19)(q21;p13) translocation resulting in a MECT1-MAML2 fusion in which the CREB-binding domain of the CREB coactivator MECT1 (also known as CRTC1, TORC1 or WAMTP1) is fused to the transactivation domain of the Notch coactivator MAML2. To gain further insights into the molecular pathogenesis of MECs, we...

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PMID: 16444749
DOI: 10.1002/gcc.20306

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