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Article

Constitutive expression of γ-H2AX has prognostic relevance in triple negative breast cancer.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 Oct 2011

Nagelkerke Anika, van Kuijk Simon J A, Sweep Fred C G J, Nagtegaal Iris D, Hoogerbrugge Nicoline, Martens John W M, Timmermans Mieke A, van Laarhoven Hanneke W M, Bussink Johan, Span Paul N

Abstract excerpt

BACKGROUND AND PURPOSE: Constitutive γ-H2AX expression might indicate disruption of the DNA damage repair pathway, genomic instability, or shortened telomeric ends. Here, we quantified expression of endogenous γ-H2AX and its downstream factor 53BP1 in a large number of breast cancer cell lines (n=54) and a node-negative breast cancer cohort that had not received adjuvant systemic treatment (n=122). MATERIALS AND...

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Identifiers

PMID: 21840613
DOI: 10.1016/j.radonc.2011.07.009

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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