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Article

Poor prognosis of constitutive γ-H2AX expressing triple-negative breast cancers is associated with telomere length.

Biomarkers in medicine - 1 Jan 2015

Nagelkerke Anika, van Kuijk Simon J A, Martens John W, Sweep Fred C G J, Hoogerbrugge Nicoline, Bussink Johan, Span Paul N

Abstract excerpt

AIM: Here, we set out to establish whether endogenous γ-H2AX is a biomarker in triple-negative breast cancer. METHODS: We explored the association of γ-H2AX with mutation status and sensitivity to 139 different anticancer drugs in up to 41 breast cancer cell lines. Further, we correlated γ-H2AX expression in breast cancer tumor tissues with telomere length. RESULTS: γ-H2AX positive breast cancer cells exhibit...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25808442
DOI: 10.2217/bmm.15.2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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