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Imaging DNA Damage <i>In Vivo</i> Using γH2AX-Targeted Immunoconjugates

17 May 2011

Abstract excerpt

DNA damage responses (DDR) occur during oncogenesis and therapeutic responses to DNA damaging cytotoxic drugs. Thus, a real-time method to image DNA damage in vivo would be useful to diagnose cancer and monitor its treatment. Toward this end, we have developed fluorophore- and radioisotope-labeled immunoconjugates to target a DDR signaling protein, phosphorylated histone H2A variant H2AX (γH2AX), which forms foci...

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PMID: 21586614
DOI: 10.1158/0008-5472.can-10-4587

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