Article
Serial daptomycin selection generates daptomycin-nonsusceptible Staphylococcus aureus strains with a heterogeneous vancomycin-intermediate phenotype.
Antimicrobial agents and chemotherapy - 1 Dec 2008
Camargo Ilana Lopes Baratella da Cunha, Neoh Hui-Min, Cui Longzhu, Hiramatsu Keiichi
Abstract excerpt
In order to better understand the mechanism of daptomycin resistance, we generated a daptomycin-nonsusceptible derivative strain, strain 10*3d1 (MIC = 3.0 microg/ml), by in vitro exposure of methicillin-resistant Staphylococcus aureus strain N315DeltaIP (MIC = 0.5 microg/ml) to daptomycin. We also obtained a daptomycin-susceptible phenotypic revertant strain, strain 10*3d1-10 (MIC = 1.0 microg/ml), by passaging...
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