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Article

Biological Activities of RUNX1 Mutants Predict Secondary Acute Leukemia Transformation from Chronic Myelomonocytic Leukemia and Myelodysplastic Syndromes.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2015

Tsai Shu-Chun, Shih Lee-Yung, Liang Sung-Tzu, Huang Ying-Jung, Kuo Ming-Chung, Huang Chein-Fuang, Shih Yu-Shu, Lin Tung-Huei, Chiu Ming-Chun, Liang Der-Cherng

Abstract excerpt

PURPOSE: Transcription factor RUNX1 is essential for normal hematopoiesis. High mutation frequencies of RUNX1 gene in chronic myelomonocytic leukemia (CMML) and myelodysplastic syndromes (MDS) have been described, whereas the biologic significances of the mutations were not investigated. Here, we aimed to correlate the biologic activities of the RUNX1 mutants with the clinical outcomes of patients. EXPERIMENTAL...

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Share to Cell Transformation, Neoplastic
Share to Core Binding Factor Alpha 2 Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to HEK293 Cells

Share to Leukemia, Myelomonocytic, Chronic

Share to Myelodysplastic Syndromes

Share to Neoplasm Proteins

Share to Receptor, Macrophage Colony-Stimulating Factor

Source

Identifiers

PMID: 25840971
DOI: 10.1158/1078-0432.CCR-14-2203

Genes

RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Biological Activities of RUNX1 Mutants Predict Secondary Acute Leukemia Transformation from Chronic Myelomonocytic Leukemia and Myelodysplastic Syndromes.PMID 25840971Read ↗

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