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RUNX1 Upregulation by Cytotoxic Drugs Promotes Apoptosis

23 Oct 2017

Abstract excerpt

Abstract Mutations in the RUNX1 gene have been associated with chemotherapy resistance and poor prognosis in patients with acute myeloid leukemia (AML), T-cell acute lymphoblastic leukemia, and myelodysplastic syndromes. However, the underlying mechanisms connecting RUNX1 to the success of therapy remain elusive. Here we explore the hypothesis that RUNX1 is directly involved in the response of hematopoietic cells...

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PMID: 29055018
DOI: 10.1158/0008-5472.can-17-0319

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